ALITOFATIB

Brief description:Tofacitinib is an oral small-molecule Janus kinase (JAK) inhibitor. JAKs are intracellular enzymes that transmit signals arising from cytokine or growth factor-receptor interactions on the cell membrane, influencing hematopoietic and immune cell function. Tofacitinib works by selectively inhibiting JAK1 and JAK3 kinase activity, blocking the JAK-STAT signaling pathway. This action inhibits the signal transduction of various pro-inflammatory cytokines (e.g., IL-6, IL-7, IL-15, IL-21), reduces the

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private

Release time

2020-07-21

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Product details

Generic Name

Tofacitinib Citrate Tablets

Mechanism of Action

Tofacitinib is an oral small-molecule Janus kinase (JAK) inhibitor. JAKs are intracellular enzymes that transmit signals arising from cytokine or growth factor-receptor interactions on the cell membrane, influencing hematopoietic and immune cell function. Tofacitinib works by selectively inhibiting JAK1 and JAK3 kinase activity, blocking the JAK-STAT signaling pathway. This action inhibits the signal transduction of various pro-inflammatory cytokines (e.g., IL-6, IL-7, IL-15, IL-21), reduces the release of inflammatory mediators, and alleviates synovial inflammation and tissue damage in joints

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Asian Frontier Pharmaceutical Information Co., Ltd.
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+86 13382285011
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No. 88, Moumou Industrial Zone, Tianhe District, Guangzhou City, Guangdong Province
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504051920@qq.com

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ALITOFATIB

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